Research chemicals are synthetic or semi-synthetic molecules that are designed specifically to circumvent drug laws. They are created to mimic the effects of prohibited substances. They can often be purchased online, often labelled as ‘Not for Human Consumption’ to minimize the liability of the people selling them. Due to their constantly evolving nature, their relative harms are unknown compared to the substances they intend to mimic.
The most popular research chemicals are substances that mimic popular psychedelics like LSD and MDMA. Here, we’ll run through some well-known research chemicals, and we’ll tell you everything we know about their legality.
1P-LSD it’s a research chemicals like LSD
1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is a novel semi-synthetic psychedelic substance of the lysergamide class. 1P-LSD is chemically related to LSD and is reported to produce near-identical effects. Little is known about the pharmacology of 1P-LSD, but it likely produces its psychedelic effects by acting on serotonin receptors in the brain.
The original synthesis date of 1P-LSD is not known. Reports of 1P-LSD use first surfaced in 2015 subsequent to its appearance on the online research chemical market. It was marketed as a legal alternative to LSD alongside novel lysergamides like ALD-52, ETH-LAD and AL-LAD.
User reports indicate that the subjective effects of 1P-LSD are extremely similar to those of LSD. 1P-LSD is theorized to act as a prodrug for LSD. The similarities in chemical structure between 1P-LSD and LSD predicts a near-identical effect profile, likely differing mainly in its rate of absorption and duration. Notable effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. Its classical psychedelic effects and favorable tolerability has led it to become popular among novel psychoactive substance users, particularly those seeking entheogenic experiences.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-LSD. It is presumed to have a similar toxicity and risk profile as LSD, although no evidence currently exists to support this. It is highly advised to use harm reduction practices if using this substance.
1P-LSD CHEMISTRY -1P LSD SHOP
1P-LSD is a molecule of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH3CH2CO- bound to an amino group. 1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.
1P LSD Pharmacology
As with LSD, 1P-LSD likely acts as a partial agonist at the 5-HT2A receptor. The psychedelic effects are thought to primarily come from its efficacy at the 5-HT2A receptors distributed throughout the brain. It also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine, due to the structural similarity it shares with LSD. However, the precise role of these interactions and how they result in the psychedelic experience require further investigation.
It has been theorized that 1P-LSD may act as a prodrug for LSD. While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum. Follow-up studies are currently being conducted to compare the affinity and selectivity of LSD and 1P-LSD at 5-HT receptors, and to determine whether 1P-LSD is hydrolyzed to LSD in vivo. Otherwise, it is possible that 1P-LSD may be capable of exerting its own psychedelic effect.
1P-LSD Subjective effects
Anecdotal reports from many users suggest that the subjective effects of 1P-LSD are so similar to that of LSD so as to be virtually indistinguishable from one another. In comparison to other psychedelics such as psilocybin, LSA and ayahuasca, 1P-LSD is significantly more stimulating and fast-paced regarding the specific style of its physical and cognitive effects.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
1P LSD Physical effects
Stimulation – 1P-LSD is usually regarded as very energetic and stimulating without being forced. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocybin which are generally sedating and relaxed.
Spontaneous bodily sensations – The “body high” of 1P-LSD can be characterized as proportionally very intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast-moving, sharp and location-specific tingling sensation. For some, it is manifested spontaneously at different, unpredictable points throughout the trip, but for most, it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. At moderate to high doses of 1P-LSD, this sensation often approaches its highest level and can become so overwhelming that people may find themselves debilitated with pleasurable sensations.
Physical euphoria – It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as extreme physical discomfort without any apparent reason.
Tactile enhancement – Feelings of enhanced tactile sensations are consistently present at moderate levels throughout most 1P-LSD experiences. If level 8A geometry is reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person’s entire body all at once is consistently present.
Stamina enhancement – This is generally mild in comparison to the stamina enhancement produced by traditional stimulants.
- Appetite suppression
- Bodily control enhancement
- Difficulty urinating
- Excessive yawning – This effect is significantly less pronounced than it is with psilocybin and its related compounds, the four-position substituted tryptamines.
- Nausea – Mild nausea is occasionally reported when consumed in moderate to high dosages and either passes instantly soon after the user has vomited or gradually fades by itself as the peak sets in.
- Increased blood pressureIncreased heart rate
- Increased perspiration
- Muscle contractions
- Muscle spasms
- Pupil dilation
- Increased salivation
- Vasoconstriction – Vasoconstriction may lead to users feeling cold, especially in the extremities.
- Seizure – The likelihood is largely extrapolated from the seizures that have been reported from the use of LSD.
It is thought to mainly be a risk in those who are genetically predisposed to them, particularly while accompanied by physically taxing conditions such as states of dehydration, fatigue, undernourishment or overheating.
1P-LSD for sell